Osteogenesis imperfecta

Over time, individuals with osteogenesis imperfecta may develop articular cartilage wear, commonly known as arthrosis. Age is a contributing factor, but several main factors determine the onset of arthrosis, including repeated fractures that can impact joint function, poor alignment of extremities affecting joint biomechanics, and ligament laxity.

The knees and hips are primarily affected, resulting in joint pain and occasional inflammation. Initially, pain management and rest, along with analgesics, may suffice. However, in some cases, the only viable solution for maintaining functional and pain-free joints is surgical intervention involving the replacement of the affected joint with a prosthetic implant. While joint replacement surgery is common among elderly individuals without OI, it poses unique challenges for OI patients due to existing bone malformations and compromised bone quality for prosthesis anchoring. Therefore, careful consideration of the optimal timing for surgery is crucial, accompanied by thorough preoperative preparation tailored to the specific needs of each patient.