Osteogenesis imperfecta

Others

• OI from the cellular and molecular perspective
• The bone in OI
• Other orthopedic disorders caused by OI
  • 1. Spine
  • 2. Deformities of the extremities
  • 3. Joints and soft tissues
  • Summary chapter 3
• Oro-cranial disorders in OI
• Hearing in OI
• Vision and OI
• Other clinical features of OI
• Results of the study about osteogenesis imperfecta (Rare Commons)

Summary chapter 3

• Vertebral fractures are relatively common in osteogenesis imperfecta (OI) and can occur in any disease variant. These fractures may sometimes be asymptomatic, underscoring the importance of periodic lateral X-rays of the spine to enable early detection.
• A characteristic of children, as opposed to adults, is their ability to remodel the vertebral bodies following fractures, restoring both shape and volume close to normal. This remodelling capacity is further enhanced in children undergoing bisphosphonate treatment.
• Deviations in the alignment of the spinal column, such as scoliosis, kyphosis, and kyphoscoliosis, are frequently observed in OI patients.
• Deformities in the long bones of the lower extremities often necessitate osteotomy to facilitate realignment, along with the placement of pontomedullary rods to enhance bone strength and durability.
• Joint hyperlaxity or hypermobility in OI individuals can contribute to joint pain, sprains, and the risk of joint dislocations.

 

Last modified

27 June 2023